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Topic

AChemS January Early Career Investigator Seminar

Time

Jan 28, 2021 11:00 AM in Eastern Time (US and Canada)

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Message preview	Hi there, You are invited to a Zoom webinar. When: Jan 28, 2021 11:00 AM Eastern Time (US and Canada) Topic: AChemS January Early Career Investigator Seminar Register in advance for this webinar: https://spltrak.zoom.us/webinar/register/WN_bM3L0fVZSNewqpMQUhRhFQ After registering, you will receive a confirmation email containing information about joining the webinar. ---------- Webinar Speakers Leveraging olfaction to study social behavior in the mouse (Lisa Stowers, PhD ) Courtship behavior requires functioning of a variety of neural computations including sensation, interoception, learning, and memory. How and where these functions alter behavior is largely unknown. The Stowers lab is leveraging the ability of specialized olfactory cues, pheromones, to specifically activate and therefore identify and study courtship circuits in the mouse. We are interested in identifying general circuit principles (specific brain nodes and information flow) that are common to all individuals, and to additionally study how experience, gender, age, and internal state modulate and personalize behavior. We are solving the structure and logic of two complete sensory to motor courtship circuits to compare and contrast their strategies of how the brain generates innate behavior. Beyond single odorants: Studying the contribution of complex receptor interactions to the olfactory code (Casey Trimmer, PhD ) Although natural odors such as rose or coffee are complex mixtures of hundreds of different odor molecules, cell-based studies of odorant receptor (OR) activation most commonly focus on individual odorants, leaving more complex interactions, such as antagonism, hidden. Our group uses simple binary mixtures to reveal complex OR behavior, including inhibition and enhancement. Using both in vitro studies and psychophysics, we demonstrate the prevalence of these phenomena and their contribution to the olfactory code. Our work illustrates how agonism and modulation may serve to increase the coding capacity of the olfactory system when faced with a complex and more realistic odor environment.

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